Database : HANSEN Search on : ANEMIA HEMOLITICA [Subject descriptor] References found : 7 [refine] Displaying: 1 .. 7   in format [Detailed]

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Id: 18103 Author: Desforges, J. F; Thayer, W. W; Dawson, J. P Title: Hemolytic anemia induced by sulfoxone therapy, with investigations into the mechanisms of its production ?- Source: Boston; s.n; 1960. 5p p. ilus. Abstract: A case report is presented of a patient in whom clinical evidence of hemolytic anemia with methemoglobinemia developed upon increasing the dosage of sulfoxone which he was receiving for Hansen's disease. Administration of the drug was withdrawn for six weeks, after which studies were made with the use of radioactive iron to demosntrate the hemolytic effect of sulfoxone. By means of tagging cells of a single age group, it was shown that the suceptibility to hemolysis was related to cell age, and it was only after the red cells had been in the circulation for approximately fifty days that they were subject to the hemolytic effects of this drug. No significant biochemical defect could be demonstrated in the erythrocytes of this patient. However, the decline in activity of glucose-6-phosphate dehydrogenase and glutathione reductase in the aging red cell and the reported sensitivity to this drug of patients with red cell deficiency of glucose-6-phosphate dehydrogenase suggest that the hemolytic mechanism is related to this enzyme system. The case demonstrates that drug-induced hemolytic anemia of this type may occur without demonstrable enzymatic defect of the erythrocytes. The observation that patients appear to compensate for the hemolytic anemia and methemoglobinemia if maintained on this drug may be explained by the fact that the older cells containing less adequate enzyme systems are removed from the circulation and an equilibrium is maintained by increased production of red cells with a shorter age span. Descriptors: HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENOSTATICOS/sangue HANSENOSTATICOS/uso terap ANEMIA HEMOLITICA/ind quim ANEMIA HEMOLITICA/diag ANEMIA HEMOLITICA/etiol - HANSENIASE/clas  HANSENIASE/compl  HANSENIASE/diag  HANSENIASE/terap Limits: RELATO DE CASO Location: BR191.1; 00720/s

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Id: 13444 Author: Tomecki, Kenneth J; Catalano, Charles J Title: Dapsone hypersensitivity ..- Source: s.l; s.n; jan. 1981. 2 p. . Abstract: A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this sulfone syndrome, an uncommon, potentially serious, side effect of dapsone therapy.(AU). Descriptors: ACNE VULGAR/quimioter ANEMIA HEMOLITICA/etiol DAPSONA/ef adv ERUPCAO POR DROGA/etiol HIPERSENSIBILIDADE A DROGAS/diag HEPATITE TOXICA/etiol DOENCAS LINFATICAS/ind quim SINDROME Limits: RELATO DE CASO HUMANO FEMININO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00741/s

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Id: 13263 Author: Tomecki, Kenneth J; Catalano, Charles J Title: Dapsone hypersensitivity ..- Source: s.l; s.n; jan. 1981. 2 p. . Abstract: A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this sulfone syndrome, an uncommon, potentially serious, side effect of dapsone therapy.(AU). Descriptors: ACNE VULGAR/quimioter ANEMIA HEMOLITICA/etiol DAPSONA/ef adv ERUPCAO POR DROGA/etiol HIPERSENSIBILIDADE A DROGAS/diag HEPATITE TOXICA/etiol DOENCAS LINFATICAS/ind quim SINDROME Limits: RELATO DE CASO HUMANO FEMININO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00724/s

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Id: 13243 Author: Kenner, D. J; Holt, K; Agnello, R; Chester, G. H Title: Permanent retinal damage following massive dapsone overdose ..- Source: s.l; s.n; oct. 1980. 4 p. ilus, graf. Abstract: A massive dose of 7.5 g of 4,4'-diamino, diphenyl sulphone (dapsone) taken as a suicide attempt in a patient on long-term therapy for tuberculoid leprosy resulted in permanent bilateral retinal necrosis, previously unreported side effect of this drug. The patient developed a severe haemolytic anaemia, methaemoglobinaemia, and acute renal failure requiring peritoneal dialysis. It is proposed that the retinal damage was due to a combination of severe hypoxaemia and the physical effects of red cell fragmentation producing vascular occlusion in the macular and perimacular region, with consequent ischaemic necrosis...(AU). Descriptors: ANEMIA HEMOLITICA/ind quim ANGIOFLUORESCEINOGRAFIA INSUFICIÊNCIA RENAL AGUDA/ind quim MACULA LUTEA METEMOGLOBINEMIA/ind quim DAPSONA/env NECROSE DOENCAS RETINIANAS/ind quim TENTATIVA DE SUICIDIO Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00677/s

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Id: 9588 Author: Malfara, Wilson Roberto Title: Efeito de antagonistas de receptores H2 na metemoglobinemia induzida pela dapsona em ratos ?- Source: Ribeirao Preto; s.n; 2000. 114 p. ilus, tab, graf. Thesis: Present for Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto presented for the degree Mestre. Abstract: Dapsona, farmaco bacteriostatico utilizado no tratamento da hanseniase, vem sendo associado a intercorrencias clinicas, principalmente devido a sua hemotoxicidade. A N-hidroxilacao, uma das principais vias de biotransformacao da dapsona vem sendo associada constantemente a quadros de metemoglobinemia decorrentes do uso da dapsona. Com objetivo de se verificar a inibicao reversivel desta via de bioativacao toxicologica, sem alterar os caminhos de detoxificacao do farmaco, a aceltilacao citosolica, a cimetidina, ranitidina e famotidina foram administradas concomitantemente a dapsona em ratos machos Wistar, com peso variando entre 200 e 250g divididos em 30 grupos (n=6), em estudo de doses unicas e multiplas. Apos as administracoes, os ratos foram submetidos a coleta de sangue(AU). Descriptors: HANSENIASE DAPSONA ANEMIA HEMOLITICA CIMETIDINA CROMATOGRAFIA LIQUIDA ANALISE ESTATISTICA TOXICOLOGIA METEMOGLOBINEMIA Location: BR191.1; WC335.102, M294e

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Id: 9353 Author: Kulkarni, A. G Title: Treatment of leprosy ..- Source: s.l; s.n; 1992. 1 p. . Descriptors: ANEMIA HEMOLITICA CLOROQUINA DEFICIENCIA DE GLUCOFOSFATO DESIDROGENASE HANSENIASE HANSENIASE Location: BR191.1; 06447/s

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Id: 3659 Author: Ramanujam, K; Smith, Michael Title: Haemolytic anaemia during treatment of leprosy with diaminodiphenylsulphone by mouth ..- Source: s.l; s.n; 1951. 2 p. . Descriptors: HANSENIASE ANEMIA HEMOLITICA Location: BR191.1; 02498/s

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